A gold color metal and enamel device 1 3/16 inches (3.02 cm) in height overall consisting of a red Greek cross bearing an heraldic fountain all between at top along the outer edge a white band bearing three gold fleurs-de-lis, and in base, a maroon scroll semi-circular from the lower edge of the lateral arms, inscribed in gold letters, "DIEU LE GURIT," (translation, "God Heals Him").
Maroon and white are the colors used by the Army Medical Department. The red cross and fountain are symbolic of aid and renewal and refer to the overall mission. Three gold fleurs-de-lis on a white field, taken from the flag of New Orleans, Louisiana, denote the unit's home station.
The distinctive unit insignia was originally approved for the 159th Evacuation Hospital, Louisiana Army National Guard on 7 February 1973. It was redesignated for the 159th Combat Support Hospital, Louisiana Army National Guard on 27 November 1974.